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introduction propranolol, a nonselective β-blocker, exerts an indirect effect on the vasculature by leaving α-adrenergic receptors unopposed, resulting in peripheral vasoconstriction. we have previously shown that propranolol diminishes peripheral blood following burn injury by increasing vascular resistance. the purpose of this study was to investigate whether wound healing and perioperative hemodynamics are affected by propranolol administration in severely burned adults. methods sixty-nine adult patients with burns covering ≥30% of the total body surface area (tbsa) were enrolled in this irb-approved study. patients received standard burn care with (n = 35) or without (control, n = 34) propranolol. propranolol was administered within 48 hours of burns and given throughout hospital discharge to decrease heart rate by approximately 20% from admission levels. wound healing was determined by comparing the time between grafting procedures. blood loss was determined by comparing pre- and postoperative hematocrit while factoring in operative graft area. data were collected between first admission and first discharge. results demographics, burn size, and mortality were comparable in the control and propranolol groups. patients in the propranolol group received an average propranolol dose of 3.3 ± 3.0 mg/kg/day. daily average heart rate over the first 30 days was significantly lower in the propranolol group (p <0.05). the average number of days between skin grafting procedures was also lower in propranolol patients (10 ± 5 days) than in control patients (17 ± 12 days; p = 0.02), indicative of a faster donor site healing time in the propranolol group. packed red blood cell infusion was similar between groups (control 5.3 ± 5.4 units vs. propranolol 4.4 ± 3.1 units, p = 0.89). propranolol was associated with a 5 to 7% improvement in perioperative hematocrit during grafting procedures of 4,000 to 16,000 cm2 compared to control (p = 0.002). conclusions administration of propranolol during the acute hospitalization period diminishes blood loss during skin grafting procedures and markedly improves wound healing in severely burned adults. as burn patients require serial surgical interventions for motor and cosmetic repair, restricting blood loss during operative intervention is optimal.
in recent years, platelet rich plasma (prp) therapy has become a widely used regenerative treatment, helping individuals recover from injuries, improve skin
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discover the benefits of peptide therapy for injury repair after surgery with the help of regenerative orthopedics.
our dedicated wound care centers in philadelphia & south jersey offer expert wound care & hyperbaric oxygen therapy to help you heal from chronic wounds.
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watch the state advocacy summit keynote address of 2022, held virtually in lieu of an in-person conference, "healing the healer: making advocacy personal."
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backgroundthree phases are often involved in the intricate process of wound healing: inflammatory exudation, cell proliferation, and tissue remodeling. it is...
at prime dentistry, we prioritize the integration of cutting-edge techniques and advancements in oral and maxillofacial surgery procedures to deliver exceptional dental care and superior treatment outcomes.
the irradiation leads to delayed wound healing and the paradigms that can enhance the healing of irradiated wound will be useful, especially in conditions where wounds are exposed to ionizing radiation before or after surgery.
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during neonatal development, tendons undergo a well-orchestrated process whereby extensive structural and compositional changes occur in synchrony to produce a normal tissue. conversely, during the repair response to injury, structural and compositional changes occur, but a mechanically inferior ten …
gifts to the children’s fund are unrestricted, meaning the funds are used where the need is greatest. it touches all areas of children’s hospital of philadelphia, and furthers the hospital’s mission. supporting the children’s fund enables our critical work of saving children’s lives. it also ensures that children have access to one of the nation’s best children’s hospitals.
stem cells in gum tissue release proteins that appear to help repair cuts about twice as fast as seen in skin.
daisy + co. offers compassionate trauma therapy to help you reclaim your peace and strength so that you can live a fulfilling and happy life. free consults!
daisy + co. offers compassionate trauma therapy to help you reclaim your peace and strength so that you can live a fulfilling and happy life. free consults!
europe pmc is an archive of life sciences journal literature.
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nfed will host a wound healing conference in collaboration with the children's hospital of philadelphia (chop). we are thrilled to share that the national
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abstract. wound healing is a complex homeostatic response to injury that engages numerous cellular activities, processes, and cell-to-cell interactions. th
timely and effective wound care treatment is critical to patient outcomes and the overall cost of care, so we’ve made a commitment to help. our clinical team works closely with case managers and providers to develop comprehensive care strategies that incorporate innovative products and services to expedite and accelerate wound treatment.
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emdr intensives are often scheduled for multiple hours or days at a time instead of one hour a week. this allows a client to experience faster relief.
the redeemer wound care center, located on the hospital campus in northeast philadelphia, offers hyperbaric oxygen therapy (hbot) to help reduce swelling, resist infection and accelerate healing. learn more and see if you’re a candidate.
researchers set out to determine whether and how gum-derived stem cells play a role in accelerated wound healing. their results, indicating that these cells secrete tiny vesicles packed with signaling proteins, point the way forward for therapeutic strategies that aim to harness the prowess of stem cells to treat delayed wound healing as well as other conditions that involve an overactive inflammatory response, such as autoimmune diseases.
significance: rapid recruitment and activation of macrophages may accelerate wound healing. such accelerated healing was observed in wounds and burns of experimental animals treated with α-gal nanoparticles. recent advances: α-gal nanoparticles ...
explore the science of accelerated resolution therapy (art) and its role in healing trauma. understand how trauma affects the brain, the significance of bilateral stimulation, and how art harnesses the brain
hydrogels show great potential as biocompatible materials with a wide variety of applications.
biorxiv - the preprint server for biology, operated by cold spring harbor laboratory, a research and educational institution
chronic wounds are characterized by a persistent, hyper-inflammatory environment that prevents progression to regenerative wound closure. such chronic wounds are especially common in diabetic patients, often requiring distal limb amputation, but occur in non-diabetic, elderly patients as well. induced expression of hoxa3, a member of the homeobox family of body patterning and master regulatory transcription factors, has been shown to accelerate wound closure in diabetic mice when applied topically as a plasmid encased in a hydrogel. we now provide independent replication of those foundational in vivo diabetic wound closure studies, observing 16% faster healing (3.3 mm wounds vs 3.9 mm wounds at day 9 post original injury of 6 mm diameter) under treatment with observable microscopic benefits. we then expand upon these findings with minimal dose threshold estimation of 1 μg hoxa3 plasmid delivered topically at a weekly interval. furthermore, we observed similarities in natural wound healing rates between aged non-diabetic mice and young diabetic mice, which provided motivation to test topical hoxa3 plasmid in aged non-diabetic mice. we observed that hoxa3 treatment achieved complete wound closure (0 mm diameter) at 2 weeks whereas untreated wounds were only 50% closed (3 mm wound diameter). we did not observe any gross adverse effects macroscopically or via histology in these short studies. whether as a plasmid or future alternative modality, topical hoxa3 is an attractive translational candidate for chronic wounds.